Medical Laboratory Scientist (MLS) ASCP Practice Exam 2025 – Your Comprehensive All-in-One Guide to Exam Success!

Hodgkin disease, a type of lymphoma, is associated with vitamin B12 deficiency due to factors related to the disease itself and its impact on the gastrointestinal system. The malignancy can lead to malabsorption syndromes, where the body struggles to absorb essential nutrients effectively, including vitamin B12.

Vitamin B12 is crucial for red blood cell formation, neurological function, and DNA synthesis. In the context of Hodgkin disease, the presence of the disease may result in dietary restrictions, gastrointestinal complications, or the effects of treatments such as chemotherapy, all of which can exacerbate the risk of developing a deficiency in this vitamin.

The other options, while they represent various vitamin deficiencies, are not specifically or commonly linked to Hodgkin disease in the same way. Vitamin B1 and B6 have other clinical correlations, and vitamin D, although important for immune function, is not directly tied to the disease process of Hodgkin lymphoma. Therefore, vitamin B12 deficiency is the most relevant deficiency associated with Hodgkin disease.